Hyperplastic Heart

The putative capacity of oils of fish to affect health cardio-vasculaire converged the considerable attention on nutriture of lipide. The corporation investigations that consume high levels d'omega-3 and -9 oils just like the possible scientific studies and retrospective showed growing importance of dietary one fats.1-6 Complex mechanisms were theorized but finally the gond on the ways of synthesis of eicosanoid. The fatty and other acids of lipide as the found cholesterol in the circulation and as a part of the surface of endothelial of sanguine vessels and their muscle coat smooths, and in the small plates, furnish an important substratum for health or the vascular disease.

SMALL PLATES
The small plates play a crucial role in the relation between the lipides and atherogenesis. The small plates of blood are biochemical powerful packed packets in a membrane of phospholipid. When the small plates in the circulation are exposed to the sanguine vessels of surface of fabric of endothelial broken and to the basic collagen. they become activated to stimulate the cure of the injury.

The acid of arachidonic in the small plate forms two different eicosanoids, that serves two functions opposing. If the small plate is next to another small plate, thromboxane (TXA2) is formed (500 millions of small plates can form as much as 2 mg of thromboxane) that stimulates aggregation and coagulative of small plates and of other components of blood. 7 For these small plates close to the endothelium, prostaglandin E2 (PGE2) is formed that stimulates hyperplasia in sanguine exposed vessel fabric and coagulative ampler discomfort next to the injury. Prostaglandins stimulates also resorption of affable bone of the calcium to the site of the injury to diminish pH of fabric and stimulates more hyperplasia.

These are normal mechanisms that continually arrives and are essential to life. If they did not arrive, the vascular lesions minors could take to the hemorrhage in escape, and healing and the repair would not arrive. Nevertheless, when there is an excess d'omega-6 fatty acids in the small plates that can produce additional quantities of acid of arachidonic to the sites of injury of sanguine vessel, the blood coagulates, the vessel that bothers, the bone resorbing, and effects of hyperplastic can surpass to annoy it moderating of the effects of prostaglandins of the fatty acids as l'omega-3's.

PATHOGENIE
The high levels of dietary fatty one can have for result of high levels of lipoprotein of low density (LDL). These complexes of protein lipide can contain big quantities of cholesterol, a good party of that can be oxidized following the manner foods modern are treated. 8 LDL can migrate to the injury sectors, is swallowed up by monocytes and macrophages, and accumulate to the site of these injuries to furnish the acid of more of arachidonic and liberates to produce radical fuel of oxidized cholesterol for the amplest damages of endothelium.

This continuous cycle, beginning with maybe a small lesion that arrives as a question of course in the endothelium, or the induced injury following the high levels of blood of fatty oxidized ones, can prove itself to be a perpetuating itself, wild, the growth of cancerlike that accumulates in the vessels that have for result atheromas and the final closing of coronary vessels that take to the heart assaults. , Hardening what's more (the sclerosis) arteries can have for result the hypertension and the loss of vascular resiliency, causing potentially the blow, aneurysms, the general loss of health and the vigor, and the predisposition to a range of other diseases.

In of other terms, if there is the vascular injury, to coagulate it normal, the vessel that bothers, the fabric that redga¨nedre of the mechanisms can lack the check following an imbalance to moderate e1cosanoids that finally is diverted from the dietary lipides. In the fabric with the potential one of cascades additional arachidonic, the exhausted ones of injury of vessel small plates additional, that stimulate to coagulate excess, the constraint of vessel and the inflammation of wall of vessel,

[Picture of Sequence of Atherosclerosis]
http://www.wysong.net/articles/lipid/figures/figure26.jpg

Which in the eicosanoids of waterfall of more of arachidonic of relacchements of bend, that stimulates the amplest aggregation of small plate, coagulative and so on, take to the closing of atheroma and vessel.

If there is not the initial injury of endothelial but it is induced high levels of blood of oxidized lipide, a similar cycle arrives. Oxidized LDL is recovered by monocytes that becomes macrophages, that accumulates in the vessel wall that causes free radical damages, the formation of the cells of foams, the deposition of calcium and the inflammation. This produce metabolites of waterfall of arachidonic, that induces more the inflammation that takes to progressive atheroma and the vessel closing. (The fig. 26, 27)

REASONING OF EMPECHEMENT
A change of the system such as the fatty oxidized ones are diminished, the saturated greases are diminished, l'omega-6 fatty are diminished (in the corporations of the west), and l'omega-3 and omega-9 rich foods potentially are increased can have for result a restoration of health to the vessel wall. Prostaglandins created by l'omega-3 and omega-9 oils create opposite the effects to the vessel that bothers, the effects clot forming of l'omega-6 oils since they compete for the same system of enzyme. (To refer itself to the fig. 18) Therefore, if l'omega-3 and -9 fatty acids are increased in the system, they exhaust the systems of enzyme acid of normally used byarachidonic to form the atherogenic promotes eicosanoids. This is the explanation presents for the showing epidemiological proof that the humans and the animals that consume higher levels of l'omega-3 and omega-9 classes of fatty acids develop far less than the problems cardio-vasculaires common than exists in the corporation of the west.

There is some proof that the incidence of disease cardio-vasculaire is proportional to the proportions of classes acids fatty in the small plates, that are in the secured bend to follow a system. The Eskimos, for example, have a higher omega-3 to l'omega-6 proportion in their fabrics that reflect their high system of fish, that is in the bend linked to their low risk of disease cardio-vasculaire in comparison of the nations of the west. (Fig. 28)

[The Formation OF Picture of Atheroma]
http://www.wysong.net/articles/lipid/figures/figure27.jpg

This is of not to say l'omega-6 fatty acids as linoleic are harmful by itself. The balance is key. In fact if sufficient linoleic is not present, atherosclerosis can result as testified in a selection of species.9,10

ASPIRIN
While changing the balance of these same systems of enzyme of eicosanoid, the aspirin also is believed to exercise his effect as an agent of anticlotting in the disease cardio-vasculaire. The aspirin is a specific suppressant (acetylator) of cyclooxygenase that normally is used to convert the acid of arachidonic in TXA2 and PGE2. The inhibition of the aspirin of clot that forms TXA2 is several longer days than his effect on the anticoagulating and the vasodilating PGE2. Thus the net effect is the clot inhibition. (To refer itself to the fig. 19)

[The Oil/Big Picture of Comparative Dietary Composition]
http://www.wysong.net/articles/lipid/figures/figure28.jpg

Nevertheless, the aspirin is a bandage. It does not address the initial cause, that is dietary impropriety. This is also not without its dangers since it can precipitate allergic reactions as the asthma while diverting the acid of arachidonic in the way of leukotriene of lipoxygenase and can increase in fact to coagulate small plate if given jointly with the fish oils. 11

The additional consumption of fatty oxidized and the fatty acids of l'omega-6 family will supply the system of atherosclerotic. The additional first matters can surpass the capacity of moderating ones. If the initial cause is dietary, the ultimate solution also must be therefore dietary, not pharmacologic. It is ironic that the 80 millions of aspirin tablets taken daily by Americans are able in the big party is necessary to cancel the effects of 15 million pounds d'omega-6-predominant treated polyunsaturated oils.

NUTRIMENTS
A lot of found nutriments in the foods have the capacity to block or to modulate the synthesis of prostaglandin. These include found composites of sulfur in the garlic, the vegetables of onions and cruciferous, and the various minerals, notably the zinc of cations of divalent, the copper, the lithium, money, the selenium, and calcium. 12 a selection of fresh entire foods, (raw if possible) grown on the rich nutritious grounds (as opposed to modern agribusiness mines grounds where only of the nitrogen, phosphorus and the potassium -- the fertilizers of NPK -- are replaced) furnishes the body with the first matters that increase the nutrition acid, fatty and correct and Can Diminish or avoid the need for the potentially dangerous drugs.

The other factors of nonpharmacologic that can help products the profiles of lipide more "friendly" include diminished tension, the increased exercise and the elimination of tobacco and maybe the caffeine. 13 moisturizes Extremely refined carbons and the sugar systems increase the risk of disease cardio-vasculaire maybe by the increased reactions of glycosylation, the increased lipoprotein (one) the levels and the fading levels of HDL. 14 Calcium to 800 mg by the day can diminish cholestero1.15 lacks Chrome can diminish factor of tolerance of glucose and affects thus metabolism of sugar and affects unfavorably The lipide proflies.16Legumes, soluble fiber, the garlic and the onions can diminish levels of cholesterol. 17 vitamins C to 1000 mg by the day and the vitamin E to 200-400 I. U. by the day are excellent antioxidants and can diminish the glycosylation reactions, the cholesterol of decrease and the increase HDL'S.18 Pantethine, a drift of acid of pantothenic to 300 mg. 3-4 daily times, 19 and nicotinic acid of 1-4 grams can absolutely affect daily lipides. The nicotinic acid is in fact one of the few agents able to lower checked genetically Lp (one) the levels. 20 l-carnitine, an amino acid, to 1000 mg by the day can improve hyperlipoproteinemia. 21

These nutriments are furnished in a system of raw, entire and varied food. Some researchers dispute themselves nevertheless that the therapeutic levels of some nutriments are not possible of consume simply of the natural foods. An accumulated deficit of a life of dietary indiscretion can demand in fact a sprout. The disease, an extraordinary event, can demand extraordinary measures to carry out a remedy. But before consuming the isolated nutriment becomes well conscious of its merits and of faults since some nutriments can present poisonousnesses or imbalances to the certain levels. The direction by a professional of services of nutritious well qualified health would be counseled for does not import that with the current disease that desires to use isolated nutriments in therapy.

As mentioned in the preceding chapter, the case for the link between the disease of system and heart is not closed. Someone dispute themselves that the hypothesis of system heart began, remains, and growing because of the support of institutions and because of the powerful personalities that subserve health diseases gigantic and the food industries. 22 Someone calculated that for the persons aged 20-62 that a program of the very life of reduction of cholesterol could increase the life length three days to thirty months. 23 Same Misters William Osler, the doctor the most extremely respected of his time, said in 1879 that the arterial degradation could arrive same A a young age and was because of "the high pressure in that the life of men, and the habit to work the machine to his capacity maximum," not too in to eat and to drink. 24

It is almost certain that the unique home on the system or the exercise, for example, lacks the brand. It neglects factors equally of the important ones as esteem automatically, affectionate relations and feeling master of a life. 25 controversy, living aside and eat in a context of MORE NATURAL synergonic can help only and is probably most potential biggest for life liberates disease.

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